Cryo-correlative light and electron microscopy (cryo-CLEM)

We harness the power of cryogenic correlative light and electron microscopy (cryo-CLEM) to target and unambiguously correlate high-resolution structures of fluorescently labelled prion assemblies to their locations in complex frozen-hydrated cellular and tissue environments, and thus gain nanoscale-resolution insights into the spatial organisation of prions captured in the snapshots of the molecular events associated with their propagation. With cryo-CLEM, we bridge the resolution gap between LM and EM. Join us as we push the boundaries of the structural biology of prions and unlock new frontiers in cell neurobiology.